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  • Association between selenium nutritional status and metabolic risk factors in men with visceral obesityAssociation between selenium nutritional status and metabolic risk factors in men with visceral obesity

Association between selenium nutritional status and metabolic risk factors in men with visceral obesityAssociation between selenium nutritional status and metabolic risk factors in men with visceral obesity

  • Date 9 Desember 2012
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Mutakina, b, Anna Meilianac,Andi Wijayac,Kenji Kobayashia,Chiho Yamazakia,Satomi Kameoa,Minato Nakazawaa,Hiroshi Koyamaa, Corresponding author contact information, E-mail the corresponding author

  • a Department of Public Health, Gunma University Graduate School of Medicine, Showa Machi 3-39-22, Maebashi, Gunma, 371-8511, Japan
  • b Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia
  • c Prodia Clinical Laboratory, Jln. Kramat Raya 150, Jakarta, 10430, Indonesia

Abstract
Background and aim

Previous evidence has suggested an association between selenium and cardiovascular disease, which is main outcome of metabolic syndrome. The aim of this study was to examine possible correlation between selenium nutritional status and metabolic risk factors in men with visceral obesity.
Methods

Plasma samples were collected from 123 Indonesian men with visceral obesity. Their metabolic risk factors and selenium nutritional status were analyzed. The eligible subjects (n = 78) were stratified according to the International Diabetes Federation: obese, obese plus one component, and obese plus two components or more. Obese plus two components or more were diagnostic criteria of metabolic syndrome. Pearson’s correlation was performed to examine the correlation in each group.
Results

In the obese group, selenium positively correlated with high-density lipoprotein (HDL) cholesterol (r = 0.390, P < 0.05) and with fatty acid binding protein-4 (FABP4) (r = 0.474, P < 0.05); glutathione peroxidase-3 (GPx3) activity was inversely correlated with FABP4 (r = −467, P < 0.05). In the obese plus one component group, GPx3 activity positively correlated with HDL cholesterol (r = 0.413, P < 0.05). In the metabolic syndrome group, selenium negatively correlated with monocytes chemoattractant protein (MCP)-1 (r = −0.429, P < 0.05).
Conclusions

These results show that the association between selenium nutritional status and metabolic risk factors is limited to particular group of obese men with or without metabolic syndrome.
Keywords

Selenium;Metabolic risk factors;Adipocytokines;Obesity;Metabolic syndrome

http://www.sciencedirect.com/science/article/pii/S0946672X12001290

Journal of Trace Elements in Medicine and Biology Available online 28 November 2012

Mutakina, b, Anna Meilianac,Andi Wijayac,Kenji Kobayashia,Chiho Yamazakia,Satomi Kameoa,Minato Nakazawaa,Hiroshi Koyamaa, Corresponding author contact information, E-mail the corresponding author

  • a Department of Public Health, Gunma University Graduate School of Medicine, Showa Machi 3-39-22, Maebashi, Gunma, 371-8511, Japan
  • b Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia
  • c Prodia Clinical Laboratory, Jln. Kramat Raya 150, Jakarta, 10430, Indonesia

Abstract

Background and aim

Previous evidence has suggested an association between selenium and cardiovascular disease, which is main outcome of metabolic syndrome. The aim of this study was to examine possible correlation between selenium nutritional status and metabolic risk factors in men with visceral obesity.

Methods

Plasma samples were collected from 123 Indonesian men with visceral obesity. Their metabolic risk factors and selenium nutritional status were analyzed. The eligible subjects (n = 78) were stratified according to the International Diabetes Federation: obese, obese plus one component, and obese plus two components or more. Obese plus two components or more were diagnostic criteria of metabolic syndrome. Pearson’s correlation was performed to examine the correlation in each group.

Results

In the obese group, selenium positively correlated with high-density lipoprotein (HDL) cholesterol (r = 0.390, P < 0.05) and with fatty acid binding protein-4 (FABP4) (r = 0.474, P < 0.05); glutathione peroxidase-3 (GPx3) activity was inversely correlated with FABP4 (r = −467, P < 0.05). In the obese plus one component group, GPx3 activity positively correlated with HDL cholesterol (r = 0.413, P < 0.05). In the metabolic syndrome group, selenium negatively correlated with monocytes chemoattractant protein (MCP)-1 (r = −0.429, P < 0.05).

Conclusions

These results show that the association between selenium nutritional status and metabolic risk factors is limited to particular group of obese men with or without metabolic syndrome.

Keywords

Selenium;Metabolic risk factors;Adipocytokines;Obesity;Metabolic syndrome

http://www.sciencedirect.com/science/article/pii/S0946672X12001290

Journal of Trace Elements in Medicine and Biology Available online 28 November 2012

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