Association between selenium nutritional status and metabolic risk factors in men with visceral obesityAssociation between selenium nutritional status and metabolic risk factors in men with visceral obesity
Mutakina, b, Anna Meilianac,Andi Wijayac,Kenji Kobayashia,Chiho Yamazakia,Satomi Kameoa,Minato Nakazawaa,Hiroshi Koyamaa, ,
- a Department of Public Health, Gunma University Graduate School of Medicine, Showa Machi 3-39-22, Maebashi, Gunma, 371-8511, Japan
- b Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia
- c Prodia Clinical Laboratory, Jln. Kramat Raya 150, Jakarta, 10430, Indonesia
Abstract
Background and aim
Previous evidence has suggested an association between selenium and cardiovascular disease, which is main outcome of metabolic syndrome. The aim of this study was to examine possible correlation between selenium nutritional status and metabolic risk factors in men with visceral obesity.
Methods
Plasma samples were collected from 123 Indonesian men with visceral obesity. Their metabolic risk factors and selenium nutritional status were analyzed. The eligible subjects (n = 78) were stratified according to the International Diabetes Federation: obese, obese plus one component, and obese plus two components or more. Obese plus two components or more were diagnostic criteria of metabolic syndrome. Pearson’s correlation was performed to examine the correlation in each group.
Results
In the obese group, selenium positively correlated with high-density lipoprotein (HDL) cholesterol (r = 0.390, P < 0.05) and with fatty acid binding protein-4 (FABP4) (r = 0.474, P < 0.05); glutathione peroxidase-3 (GPx3) activity was inversely correlated with FABP4 (r = −467, P < 0.05). In the obese plus one component group, GPx3 activity positively correlated with HDL cholesterol (r = 0.413, P < 0.05). In the metabolic syndrome group, selenium negatively correlated with monocytes chemoattractant protein (MCP)-1 (r = −0.429, P < 0.05).
Conclusions
These results show that the association between selenium nutritional status and metabolic risk factors is limited to particular group of obese men with or without metabolic syndrome.
Keywords
Selenium;Metabolic risk factors;Adipocytokines;Obesity;Metabolic syndrome
http://www.sciencedirect.com/science/article/pii/S0946672X12001290
Mutakina, b, Anna Meilianac,Andi Wijayac,Kenji Kobayashia,Chiho Yamazakia,Satomi Kameoa,Minato Nakazawaa,Hiroshi Koyamaa, ,
- a Department of Public Health, Gunma University Graduate School of Medicine, Showa Machi 3-39-22, Maebashi, Gunma, 371-8511, Japan
- b Faculty of Pharmacy, Universitas Padjadjaran, Jl. Bandung Sumedang Km 21, Jatinangor, 45363, Indonesia
- c Prodia Clinical Laboratory, Jln. Kramat Raya 150, Jakarta, 10430, Indonesia
Abstract
Background and aim
Previous evidence has suggested an association between selenium and cardiovascular disease, which is main outcome of metabolic syndrome. The aim of this study was to examine possible correlation between selenium nutritional status and metabolic risk factors in men with visceral obesity.
Methods
Plasma samples were collected from 123 Indonesian men with visceral obesity. Their metabolic risk factors and selenium nutritional status were analyzed. The eligible subjects (n = 78) were stratified according to the International Diabetes Federation: obese, obese plus one component, and obese plus two components or more. Obese plus two components or more were diagnostic criteria of metabolic syndrome. Pearson’s correlation was performed to examine the correlation in each group.
Results
In the obese group, selenium positively correlated with high-density lipoprotein (HDL) cholesterol (r = 0.390, P < 0.05) and with fatty acid binding protein-4 (FABP4) (r = 0.474, P < 0.05); glutathione peroxidase-3 (GPx3) activity was inversely correlated with FABP4 (r = −467, P < 0.05). In the obese plus one component group, GPx3 activity positively correlated with HDL cholesterol (r = 0.413, P < 0.05). In the metabolic syndrome group, selenium negatively correlated with monocytes chemoattractant protein (MCP)-1 (r = −0.429, P < 0.05).
Conclusions
These results show that the association between selenium nutritional status and metabolic risk factors is limited to particular group of obese men with or without metabolic syndrome.
Keywords
Selenium;Metabolic risk factors;Adipocytokines;Obesity;Metabolic syndrome
http://www.sciencedirect.com/science/article/pii/S0946672X12001290
Journal of Trace Elements in Medicine and Biology Available online 28 November 2012